An International Quarterly Research Journal

ACL

                                                               ISSN : 0971 - 9822

Vol   11,  No 3&4,  July-December,   2007

Asian Chemistry Letters                                                                                                          Vol. 11, Nos 3&4 (2007)1-10


Expanded modification of anti-HIV DCK analogues: Bioiosoteres, 8-substitutes change and seco-DCKs

 

Ying Chen, Qian Zhang and Peng Xia*
Department of Medicinal Chemistry, School of Pharmacy, Fudan University, Shanghai-201203, China

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During the past two decades, many dicamphanoyl-khellactone analogues (DCKs) with angular tricycle scaffold were developed as potent anti-HIV agents by Lee's group. According to bioisosterism, our group further have designed and synthesized a series of novel DCK analogues. Among them, seco-DCKs with only dicycle skeleton not only show good anti-HIV activities, but also seem to get better ADME properties than that of DCKs. This article reviews our research progress on the modification of DCKs by hetero-atom exchange in tricycle core structure, 8-substitutes change and cleavage of core cycles.

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Asian Chemistry Letters                                                                                                    Vol. 11, Nos 3&4 (2007)205-210


Synthesis of tetrathiafulvalene bismacrocycles functionalized
with carboxylic acid end groups


Mogens Brondsted Nielsena, Jan Becherb

a Department of Chemistry, University of Copenhagen, Universitetsparken5, DK-2100 Copenhagen ø, Denmark

bDepartment of Physics and Chemistry.University of Southern Denmark, Campusvej 55, DK-5230 Odense M, Denmark

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Two bis-annelated tetrathiafulvalene macrocycles containing carboxylic acid end groups were synthesized and characterized. These compounds may have potential applications in supramolecular chemistry as they contain (i) a redox-active TTF unit, (ii) a crown ether binding site for metal or ammonium ions, and (iii) CO2H groups that can be engaged in hydrogen bonding interactions. © Anita Publications. All rights reserved.

Total Refs :

Synthesis of tetrathiafulvalene bismacrocycles functionalized with carboxylic acid end groups.pdf
Mogens Brondsted Nielsen, Jan Becher

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Asian Chemistry Letters                                                                                                    Vol. 11, Nos 3&4 (2007)211-218


Substituted tetraoxa (8) circulenes


Jørgen Eskildsen1, Peter Hammershøj2, Theis K. Reenberg2, Uffe Larsen3, Michael Pittelkow, Søren Mejlsøe Leth, Richard Peck and Jørn B Christensen*
Department of Chemistry, University of Copenhagen, Universitetsparken 5, DK-2100 Copenhagen, Denmark

1Present address: Acadia Pharmaceuticals AB, P. A. Hanssonsvag 35, S-205 12 Malmo, Sweden
2Present address: Nano Science Center, University of Copenhagen, Universitetsparken5, DK-2100 Copenhagen,Denmark
3Prrtent address: Novo Nordisk A/S, Novo
Nordisk Park, DK-2760 Maløv, Denmark

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Tetraoxa (8) circulenes are an interesting class of compounds, which are accessible via tetramerization of 2,3- disubstituted 1,4-benzoquinones. This paper describes our recent work on general synthesis methods leading to these compounds. © Anita Publications. All rights reserved.

Total Refs : 18

Substituted tetraoxa (8) circulenes.pdf
Jørgen Eskildsen, Peter Hammershøj, Theis K. Reenberg, Uffe Larsen, Michael Pittelkow, Søren Mejlsøe Leth, Richard Peck and Jørn B Christensen

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Asian Chemistry Letters                                                                                                    Vol. 11, Nos 3&4 (2007)235-237


Tetraethyl ammonium periodate: An efficient oxidant for alcoholic and benzylic

oxidations catalysed by tetra-aryl porphyrins

D D Agarwala and Daisy Bhatb
aSOS Chemistry
Jiwaji University, Gwalior-470 011, India
bBhagwan Parshuram Institute of Technology (IP University)
Rohini, Delhi-110 089, India

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Alcoholic, allyllic and benzylic oxidations using substituted tetra aryl Fe (III) and Mn (III) porphyrin complexes as catalyst and tetraethyl ammonium periodate as oxidant were studied. The oxidant exhibited very good efficiency towards these oxidations with product yields ranging from 50-75%. o-substituted porphyrin complexes were found to act as better catalysts than β-pyrrole substituted. The oxidation system showed selectivity towards allylic oxidation than epoxidation of unsaturated bonds whereever present in substrate. ©Anita Publications. All rights reserved.
Key words: Alcohol, Oxidations, Tetra alkyl ammonium periodate, Benzylic oxidations, Porphyrin complexes.

Tetraethyl ammonium periodate: An efficient oxidant for alcoholic and benzylic oxidations catalysed by tetra-aryl porphyrins.pdf
D D Agarwal and Daisy Bhat

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