An International Quarterly Research Journal

ACL

                                                                                                      ISSN : 0971 - 9822

                                                                                  Vol 16, No 4, April-June, 2012

Asian Chemistry Letters                                                                                                               Vol. 16, No. 4 (2012)1-12


Formation, stability and application of microemulsions for

drug delivery: Promises and Challenges


Evren Gundogdu and H Yesim Karasulu
Department of Biopharmaceutic and Pharmacokinetic,
Faculty of Pharmacy, University of Ege, 35100 Bornova, Izmir, Turkey
Department of Pharmaceutical Technology, Faculty of Pharmacy,University of Ege, 35100 Bornova, Izmir, Turkey

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This rewiew provides information about microemulsions in relation to their structure, formation, characterization and application. Microemulsions are clear and thermodynamically stable isotropic mixtures of oil and water containing domains of nanometer dimensions stabilized by the interfacial film of surface active agents. Usually microemulsions are produced by homogenization of the corresponding compounds. Microemulsions are graphically represented as stability areas in triangular phase diagrams where each triangular corner designates a certain component. These systems are actually quaternary (pseudoternary) systems composed of an oil phase, a water phase, surfactant/s and a co-surfactant. In pharmaceutical fields, these versatile systems are currently of great technological and scientific interest to the researchers because of their potential to act as drug delivery vehicles by incorporating a wide range of drug molecules. The purpose of this rewiew is to investigate the formation, stability and application of microemulsions for drug delivery.

Keywords: Microemulsion, drug delivery, bioavailability, characterization.

Total Refs : 60

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Asian Chemistry Letters                                                                                                             Vol. 16, No. 4 (2012)13-17


Lithium Inhibits the Apoptosis of Human Osteoblastic
Cells Dose Dependently: In vitro study


Alpaslan Senkoylu1, Akin Yilmaz2, Mehmet Ali Ergun3, Mustafa N Ilhan4
Gazi University Faculty of Medicine Department of Department of Orthopaedics and Traumatology1,
Department of Medical Biology and Genetics2, Medical Genetics3,Department of Public Health4 

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Lithium is a well-known therapeutic agent for bipolar affective disorder. The effect of Lithium on H2O2 induced apoptosis of the CRL-11372 cells and optimization of its anti-apoptotic dose was aimed in this study. After one hour pretreatment with LiCO3 of 0.5-25 mM concentrations, CRL-11372 osteoblasts were treated with 100µM H2O2 and 6-12 hours time periods respectively. Apoptotic index and viability of cells were assessed with fluorescent dye quantitatively and with gel electrophoresis qualitatively. In 10 and 25 mM concentrations of LiCO3 for 6 hours and in 25 mM concentrations for 12 hours treatment inhibited the apoptotic effect of H2O2 on cultured osteoblasts with respect to the positive control. LiCO3 was shown to inhibit H2O2 induced apoptosis that also plays a critical role in osteoporosis of CRL-11372 cells in dose-dependent manner.

Keywords: Lithium, osteoblast, apoptosis, tissue culture, osteoporosis.

Total Refs : 22

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